The Mecklenburg Emergency Services said on Twitter that two people had life-threatening injuries. It was not immediately clear if anyone was in custody.
Aerial footage from television stations showed multiple police cars and officers on campus. At least one person could be seen being put on a stretcher.
Videos posted on Twitter showed police officers running in one direction while students streamed in the other direction.
It was the final day of classes for the school year; graduation ceremonies are scheduled for early May. Some students were getting ready for the summer break, and some were planning to attend an on-campus concert featuring rapper Waka Flocka Flame.
The shooting took place three days after a gunman opened fire at a synagogue in Poway, California, killing a congregant.
This article originally appeared in The New York Times.